KCNE4 — Potassium voltage-gated channel subfamily E regulatory subunit 4
KCNE4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KCNE4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Quiescence Identity Endothelial cell development | CCDC69, CLIC2, CLSTN3, CPD, EPB41L4A, FOXF1, FZD4, IGFBP7 +7 more | View in SCUBA |
| Pericytes | Cytokine Inflammatory Response Inflammatory | ADAMTS4, C11orf96, CEBPB, CEBPD, GEM, ID4, PHLDA1, RGS16 +4 more | View in SCUBA |
About the gene
| Synonyms | MiRP3 |
|---|---|
| Chromosome | 2: 223052190-223198399 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Ion channel, Potassium channel, Voltage-gated channel |
| Biological process | Ion transport, Potassium transport, Transport |
Function
Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore- forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents. May inhibit KCNQ4-mediated potassium currents
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.