PHLDA1 — Pleckstrin homology like domain family A member 1

PHLDA1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

PHLDA1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Chemokine Migration migration & adhesion	CCR6, CYTIP, DDX24, FRMD4B, G3BP2, GNG2, GPBP1, KMT2E +7 more	View in SCUBA
CD8⁺ T cells	Cytotoxic Exhausted CD8 Exhaustion	CCL3, CD2BP2, CLEC2D, CTSD, DUSP4, GZMB, NDFIP2, PRF1 +2 more	View in SCUBA
Endothelial	Inflammatory Angiogenesis Endothelial cell development	FAM241A, FAM43A, KLF6, MYC, NFATC1, PIM3, PLEKHO2, RALGDS +7 more	View in SCUBA
Fibroblasts	NF-κB Stress Response Inflammatory	EGR3, NAMPT, NCOA7, NFIL3, PHLDA2, SAT1, SLC20A1, SOD2 +3 more	View in SCUBA
Gamma-delta T cells	Heat Stress Apoptotic Stress	AMD1, DBF4, DNAJB9, DUSP2, IER5, NFKBIB, NINJ1, PMAIP1 +5 more
Glial cells	COX-2/NF-κB Inflammation Inflammation	ABL2, ARID5A, BCL3, EMP1, LMNA, PDLIM3, PTGS2	View in SCUBA
Innate lymphoid cells	ILC Survival Residency Gut residency	ARID4B, BAZ1A, BCL2A1, CD44, CSF2, CTSH, CXCL8, DUSP4 +25 more	View in SCUBA
Lymphatic endothelial	AP-1 Immediate Early Inflammation	DUSP1, EGR1, FOS, FOSB, HES1, HSPA8, IER2, JUN +7 more	View in SCUBA
Macrophages	Osmotic Stress Response Stress	ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more	View in SCUBA
Monocytes	Integrin-mediated Migration Migration & adhesion	DNAAF1, EIF4E, ITGA5, ITGB8, LMNA, MSC, NRIP3, PNP +7 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more
Pericytes	Cytokine Inflammatory Response Inflammatory	ADAMTS4, C11orf96, CEBPB, CEBPD, GEM, ID4, KCNE4, RGS16 +4 more	View in SCUBA
Smooth muscle cells	NR4A-ADAMTS Activation Stress	ADAMTS1, ADAMTS4, ADAMTS9, AVPR1A, DUSP8, HIPK2, KLF9, MYC +5 more	View in SCUBA

About the gene

Synonyms	DT1P1B11, PHRIP, TDAG51
Chromosome	12: 76025447-76031776
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Predicted intracellular proteins
Biological process	Apoptosis

Function

Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.