PEAK1 — Pseudopodium enriched atypical kinase 1
PEAK1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PEAK1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | Chromatin Remodeling DNA/chromatin regulation | DYRK1A, HERC1, KDM6A, KMT2C, MBNL1, MED13L, MRTFA, NCOA1 +2 more | View in SCUBA |
| Macrophages | MAPK Stress Kinase Inflammatory | ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1 +12 more | View in SCUBA |
| Pericytes | Pericyte Identity Signaling Developmental | ADCY3, CCDC102B, FBLIM1, NOTCH3, OLFML2B, PDGFRB, PLXDC1 | View in SCUBA |
About the gene
| Synonyms | KIAA2002, sgk269 |
|---|---|
| Chromosome | 15: 77100656-77420144 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
Function
Probable catalytically inactive kinase. Scaffolding protein that regulates the cytoskeleton to control cell spreading and migration by modulating focal adhesion dynamics. Acts as a scaffold for mediating EGFR signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.