NOTCH3 — Notch receptor 3
NOTCH3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NOTCH3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC niche interactaion Gut motility | ABCC9, ADGRF5, ANO1, CD36, CFHR1, ESAM, FHL5, HOPX +10 more | View in SCUBA |
| Pericytes | Pericyte Identity Signaling Developmental | ADCY3, CCDC102B, FBLIM1, OLFML2B, PDGFRB, PEAK1, PLXDC1 | View in SCUBA |
| Smooth muscle cells | Mural/Pericyte Identity Development | C1QTNF1, EBF1, FRMD4A, FRY, ITGA7, LGALSL, LGI4, MCAM +6 more | View in SCUBA |
About the gene
| Synonyms | CADASIL, CASIL |
|---|---|
| Chromosome | 19: 15159038-15200995 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Activator, Developmental protein, Receptor |
| Biological process | Differentiation, Notch signaling pathway, Transcription, Transcription regulation |
Function
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.