BM Collagen Production
Gene co-expression module in Pericytes
| Category | ECM production |
|---|---|
| Genes | 9 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes are COL4A2 and COL4A1 (type IV collagen, the principal structural collagen of basement membranes), COL5A3, COL18A1 (also a BM collagen with endostatin domain), SPARC (BM-associated matricellular protein), ANGPT2 (angiopoietin-2, pericyte-EC communication), ITGA1 (collagen-binding integrin), PXDN (peroxidasin, crosslinks BM collagen IV), and MEST. This is a tightly coherent BM collagen production module. Neighbors M63 (fibrillar collagens) and M64 (ECM remodeling) confirm an ECM production neighborhood. ANGPT2 adds a pericyte-specific vascular remodeling component.
Genes
ANGPT2, COL18A1, COL4A1, COL4A2, COL5A3, ITGA1, MEST, PXDN, SPARC
Most correlated modules
- Fibrotic ECM Remodeling · correlation 0.94
- Basement Membrane Assembly · correlation 0.93
- Fibrillar Collagen Production · correlation 0.90
- Fibrotic ECM Remodeling · correlation 0.89
- Pericyte Inflammatory Activation · correlation 0.87
- Pericyte Identity · correlation 0.86
- Basement Membrane Remodeling · correlation 0.83
- Pericyte Identity Signaling · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.