Fibrillar Collagen Production
Gene co-expression module in Pericytes
| Category | ECM production |
|---|---|
| Genes | 10 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 10 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes are COL1A2, COL1A1, COL3A1 (fibrillar collagens I and III, the dominant structural collagens of the intestinal stroma), COL6A1/A2/A3 (type VI collagen network), COL5A1 (fibrillar collagen), PCOLCE (procollagen C-proteinase enhancer, promotes fibrillar collagen processing), GGT5 (gamma-glutamyltransferase, stromal marker), THY1/CD90 (canonical stromal/pericyte marker). All genes are core members. This is the canonical fibrillar collagen production module in intestinal pericytes/stromal cells, upregulated in inflammation and reversed by treatment.
Genes
COL1A1, COL1A2, COL3A1, COL5A1, COL6A1, COL6A2, COL6A3, GGT5, PCOLCE, THY1
Most correlated modules
- Fibrotic ECM Remodeling · correlation 0.93
- Pericyte Inflammatory Activation · correlation 0.90
- BM Collagen Production · correlation 0.90
- Basement Membrane Assembly · correlation 0.85
- Fibrotic ECM Remodeling · correlation 0.84
- Basement Membrane Remodeling · correlation 0.84
- Complement Regulatory Pericyte · correlation 0.83
- Pericyte ECM Production · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.