YAP/TAZ Mechanosensing
Gene co-expression module in Pericytes
| Category | Developmental |
|---|---|
| Genes | 10 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
WWTR1 (TAZ, YAP/TAZ mechanosensing co-transcription factor) and ENG (endoglin, TGF-β co-receptor and canonical pericyte marker) are the dominant functional anchors. TRIOBP links actin cytoskeleton to mechanosensing. COL15A1 is a basement membrane collagen produced by pericytes. YES1 (Src-family kinase) activates YAP/TAZ. TMEM204 is an endothelial/pericyte transmembrane protein. Together these genes define a YAP/TAZ mechanotransduction program in pericytes, consistent with the module's neighborhood (M27 with BMPR2, M66 with SKIL/SMURF2 — all TGF-β superfamily-related). ENG bridges TGF-β and mechanosensing pathways in pericytes.
Genes
CARHSP1, COL15A1, ENG, MLEC, NOL4L, TMEM204, TRIOBP, VAT1, WWTR1, YES1
Most correlated modules
- Vascular Junction Adhesion · correlation 0.98
- Basement Membrane Maintenance · correlation 0.97
- BMP Receptor Signaling · correlation 0.97
- Angiogenic Receptor Signaling · correlation 0.96
- Actin-ERM Migration · correlation 0.95
- BMP-SMAD Signaling · correlation 0.95
- G1 Cell Cycle Entry · correlation 0.95
- TGF-beta Negative Feedback · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.