Actin-ERM Migration
Gene co-expression module in Pericytes
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
MSN (moesin) and RDX (radixin) are ERM-family proteins that crosslink the actin cytoskeleton to the plasma membrane and are essential for cell shape, migration, and adhesion. DIAPH1 (diaphanous-related formin 1) drives actin polymerization and is a key regulator of cell migration. ITGA5 (integrin α5) mediates fibronectin-dependent cell-ECM adhesion and migration. FXYD5 (dysadherin) modulates cell-cell adhesion to facilitate migration. CRIP2 is a LIM-domain protein expressed in pericytes/smooth muscle that regulates cytoskeletal organization. Together these genes define a coherent cytoskeletal organization and cell migration program in pericytes, consistent with the module's neighborhood (M27 BMPR2 signaling can drive pericyte migration).
Genes
CRIP2, DIAPH1, FKBP1A, FXYD5, ITGA5, MRPL17, MSN, NAA38, RDX
Most correlated modules
- RAS Cytoskeletal Signaling · correlation 0.97
- Vascular Junction Adhesion · correlation 0.96
- G1 Cell Cycle Entry · correlation 0.96
- YAP/TAZ Mechanosensing · correlation 0.95
- BMP Receptor Signaling · correlation 0.95
- Notch Vascular Development · correlation 0.94
- TGF-beta Negative Feedback · correlation 0.94
- Golgi Vesicular Trafficking · correlation 0.93
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.