TRIOBP — TRIO and F-actin binding protein
TRIOBP belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIOBP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Vascular Barrier Integrity migration & adhesion | APCDD1, CREB3L2, DYSF, GJA1, GRAMD1A, HDAC1, IGF2R, LAMB1 +11 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Vascular Stability endothelial development | GJA1, GLT8D2, HIC1, HSD17B12, IGFBP4, KCTD12, MAF, ROBO4 +6 more | View in SCUBA |
| Macrophages | Mitotic Spindle Assembly Cell cycle | ACTL6A, AKR7A2, ANP32E, BOLA3, BUB3, CCDC167, CENPW, CENPX +34 more | View in SCUBA |
| Pericytes | YAP/TAZ Mechanosensing Developmental | CARHSP1, COL15A1, ENG, MLEC, NOL4L, TMEM204, VAT1, WWTR1 +1 more | View in SCUBA |
About the gene
| Synonyms | DFNB28, HRIHFB2122, KIAA1662, TAP68, Tara |
|---|---|
| Chromosome | 22: 37697048-37776556 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Essential for correct mitotic progression. Plays a pivotal role in the formation of stereocilia rootlets. Plays a pivotal role in the formation of stereocilia rootlets
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.