ENG — Endoglin
ENG belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENG's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Arterial EC Identity Endothelial cell development | ACVRL1, ANXA11, ATP13A2, HPCAL1, HYAL1, LDB2, MACF1, NFIB +7 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Lymphocyte Signaling Immune regulation | CDIPT, CNPY3, DBNL, IL16, LIMD2, LSM2, MAPKAPK3, PHYKPL +11 more | View in SCUBA |
| Monocytes | Tissue-destructive Macrophage Lysosomal & pahgocytosis | ACP5, ANKH, BCAT1, FABP5, ID3, IL10, KIFC3, LDLRAD4 +7 more | View in SCUBA |
| Pericytes | YAP/TAZ Mechanosensing Developmental | CARHSP1, COL15A1, MLEC, NOL4L, TMEM204, TRIOBP, VAT1, WWTR1 +1 more | View in SCUBA |
About the gene
| Synonyms | CD105, END, HHT1, ORW, ORW1 |
|---|---|
| Chromosome | 9: 127815013-127854658 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, CD markers, Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Biological process | Angiogenesis, Cell adhesion |
Function
Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis (By similarity). May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Acts as a TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.