EFEMP2 — EGF containing fibulin extracellular matrix protein 2
EFEMP2 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EFEMP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | TGF-beta ECM Remodeling ECM remodeling | ADAM10, APLP2, CCNDBP1, CYB5R3, DHRS3, GNAS, HIPK2, MGST2 +10 more | View in SCUBA |
| Pericytes | Basement Membrane Remodeling ECM remodeling | ADA, C4orf48, CYBA, DKK3, G0S2, ISG20, LAMB3, RCN3 +2 more | View in SCUBA |
| Smooth muscle cells | Basement Membrane Matrix ECM remodeling | ADH5, C4orf48, FBXL7, MLXIP, MXRA8, PRNP, RTN4, VWA1 | View in SCUBA |
About the gene
| Synonyms | FBLN4, UPH1 |
|---|---|
| Chromosome | 11: 65866441-65873592 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Plays a crucial role in elastic fiber formation in tissue, and in the formation of ultrastructural connections between elastic laminae and smooth muscle cells in the aorta, therefore participates in terminal differentiation and maturation of smooth muscle cell (SMC) and in the mechanical properties and wall integrity maintenance of the aorta. In addition, is involved in the control of collagen fibril assembly in tissue throught proteolytic activation of LOX leading to cross- linking of collagen and elastin (By similarity). Also promotes ELN coacervation and participates in the deposition of ELN coacervates on to microfibrils but also regulates ELN cross- linking through LOX interaction. Moreover adheres to the cells through heparin binding in a calcium-dependent manner and regulates vascularlar smooth muscle cells proliferation through angiotensin signaling.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.