NUDT8 — Nudix hydrolase 8
NUDT8 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NUDT8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Basal Lipid Metabolism Housekeeping | ACOT7, ADCY3, AHCY, CLN6, DENND6B, FANCL, MGLL, MPST +6 more | |
| Goblet cells | Pyroptosis Stress Response Stress | ADAM15, AURKAIP1, CDC37, CENPX, COMTD1, DDX39A, EEF1D, GSDMD +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Myeloid Commitment Myeloid development | ADA, ALDH2, CTSD, DENND6B, HCST, LAIR1, LST1, NINJ1 +4 more |
About the gene
| Synonyms | FLJ41567 |
|---|---|
| Chromosome | 11: 67627938-67629937 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Hydrolase |
Function
Acyl-CoA diphosphatase that mediates the hydrolysis of a wide range of CoA and CoA esters yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products (By similarity). Hydrolyzes short- and medium-chain acyl-CoAs, exhibiting the highest activity toward free CoA, hexanoyl-CoA, and octanoyl-CoA and the lowest activity against acetyl-CoA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.