Mitochondrial Biogenesis
Gene co-expression module in Macrophages
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 47 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 15 of 47 genes have a known function matching the annotation |
Why this annotation
Module contains multiple mitochondrial programs: ETC subunits (CYC1=Complex III, NDUFS8=Complex I, COA4=Complex IV assembly factor), TCA cycle (MDH2, SLC25A11=mitochondrial oxoglutarate/malate carrier), mitoribosome (MRPS12, MRPS15, MRPL57, MRPL4), mitochondrial translation (TUFM=elongation factor, C1QBP=mitoribosome assembly), mitochondrial import (TIMM13), and inner membrane proteins (CHCHD5, HSD17B10). ATP5F1D is ATP synthase. SNU13/SNRPD2 are spliceosomal outliers. This is a broad mitochondrial biogenesis and OxPhos module.
Genes
AIMP1, ATP5F1D, ATP5MC1, C1QBP, CCT2, CCT3, CCT7, CHCHD1, CHCHD5, COA4, COMMD8, COMMD9, COX5A, CYC1, EIF3M, FIS1, HSD17B10, IMP4, ITPA, LSM7, MDH2, MRPL4, MRPL57, MRPS12, MRPS15, NAA10, NAA20, NDUFB10, NDUFS8, NHP2, NIFK, NME1, NPM1, PDCD5, POLR2F, POLR2G, SLC25A11, SNRPC, SNRPD2, SNU13, SRM, STOML2, TIMM13, TRAPPC2L, TUFM, TXNL4A, ZNF593
Most correlated modules
- Spliceosomal snRNP · correlation 0.96
- Protein Homeostasis Mixed · correlation 0.96
- ATP Synthase Complex · correlation 0.95
- Mitochondrial Complex Assembly · correlation 0.95
- Oxidative Phosphorylation · correlation 0.95
- Proteasome UPS · correlation 0.94
- ER Protein Glycosylation · correlation 0.94
- Mitochondrial Housekeeping · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.