GTF3A — General transcription factor IIIA
GTF3A belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GTF3A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | ER stress UPR Protein processing & ER | CCT2, CDK2AP2, CRELD2, DDX39A, DNAJB11, DSTN, EIF5A, GPSM3 +9 more | View in SCUBA |
| Innate lymphoid cells | NK Cytotoxic Regulation Cytotoxicity | ARHGAP30, BIN2, CAPN12, CHD9, CLK1, CTSC, CYB5B, DDX27 +29 more | View in SCUBA |
| Macrophages | Glycolytic Metabolism Housekeeping | ARL1, ARPC5, ATP5PB, ATRAID, C4orf3, CALM1, CAPZA2, CHMP5 +30 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cyclophilin-Mediated Folding Housekeeping | B2M, BBLN, BCL7C, C12orf75, CFL1, EDF1, EIF3L, ERH +10 more |
About the gene
| Synonyms | AP2, TFIIIA |
|---|---|
| Chromosome | 13: 27424619-27435823 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins, Transcription factors |
| Molecular function | DNA-binding, RNA-binding |
| Biological process | Ribosome biogenesis, Transcription, Transcription regulation |
Function
Involved in ribosomal large subunit biogenesis. Binds the approximately 50 base pairs internal control region (ICR) of 5S ribosomal RNA genes. It is required for their RNA polymerase III- dependent transcription and may also maintain the transcription of other genes. Also binds the transcribed 5S RNA's (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.