NF-κB RNA Regulation
Gene co-expression module in Mucosal-associated invariant T cell
| Category | RNA processing & translation |
|---|---|
| Genes | 23 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 23 genes have a known function matching the annotation |
Why this annotation
Hub genes RELA (NF-κB subunit), ARIH2 (ubiquitin E3 ligase involved in NF-κB regulation), RNF11 (ubiquitin ligase, NF-κB modulator), CALR (ER chaperone), PRNP, along with multiple RNA-binding proteins (PTBP1, EIF4G2, EIF4H, HNRNPC, DDX6, STRAP) suggest a module combining NF-κB/ubiquitin signaling with RNA processing. BCLAF1 links RNA processing to apoptosis. The neighborhood context with M75 (ER stress) and M140 (NF-κB/survival) supports an activated immune signaling and RNA regulatory program.
Genes
ARIH2, ATP1A1, BCLAF1, BNIP2, CALR, COG3, DDX6, EIF4G2, EIF4H, HNRNPC, HNRNPH3, KPNA4, MAPRE1, MFSD11, PPP2CA, PRNP, PRRC2C, PTBP1, RASSF5, RELA, RNF11, SNRK, STRAP
Most correlated modules
- NF-κB Activation · correlation 0.88
- Rho GTPase Migration · correlation 0.84
- Chromatin & Splicing · correlation 0.80
- Splicing Regulation · correlation 0.80
- RUNX3 Tissue Identity · correlation 0.80
- RNA Splicing m6A · correlation 0.79
- ER Stress UPR · correlation 0.77
- Housekeeping Translation · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.