ARL3 — ADP ribosylation factor like GTPase 3
ARL3 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Integrin Rap1 Signaling migration & adhesion | ATP2B4, ATXN1, DR1, GDE1, GNA15, GRAMD1B, GTDC1, ITGA4 +8 more | View in SCUBA |
| CD8⁺ T cells | Proliferating CD8 T cell Cell cycle | AHI1, CDK6, GOLIM4, SLC7A5, SQLE, TNIP3, TNS3, VCAM1 | View in SCUBA |
| Fibroblasts | Actin Cytoskeletal Organization Cytoskeletal | ACP1, AKR7A2, CAPZB, DERL1, GDE1, LEPROTL1, LIMS1, NPTN +8 more | View in SCUBA |
About the gene
| Synonyms | ARFL3 |
|---|---|
| Chromosome | 10: 102673731-102714397 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Protein transport, Transport |
Function
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase- activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.