DERL1 — Derlin 1
DERL1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DERL1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB regulation TCR/AP1/NFKb pathway | ARIH2, CD58, CYLD, DAD1, EED, ELOVL5, NFAT5, OTULIN +9 more | View in SCUBA |
| Fibroblasts | Actin Cytoskeletal Organization Cytoskeletal | ACP1, AKR7A2, ARL3, CAPZB, GDE1, LEPROTL1, LIMS1, NPTN +8 more | View in SCUBA |
| Innate lymphoid cells | ILC Identity Program Differentiation | AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4 +29 more | View in SCUBA |
| Macrophages | Actin Cytoskeleton Organization Cytoskeletal | ACTR3, ARF1, ARHGDIA, ARPC4, CDC42, EIF4G2, GARS1, HNRNPK +20 more | View in SCUBA |
About the gene
| Synonyms | DER-1, DER1, derlin-1, FLJ13784, MGC3067, PRO2577 |
|---|---|
| Chromosome | 8: 123013170-123042302 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted membrane proteins, Transporters |
| Biological process | Host-virus interaction, Protein transport, Transport, Unfolded protein response |
Function
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane. This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.