LEPROTL1 — Leptin receptor overlapping transcript like 1

LEPROTL1 belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

LEPROTL1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	TCR signaling TCR/AP1/NFKb pathway	AP3M2, ATP1B3, CREM, CRYBG1, DCTN6, EZR, FAM177A1, FTH1 +19 more	View in SCUBA
CD8⁺ T cells	AP-1 Early Activation TCR Signaling	BTG2, CD69, EGR1, FOS, FOSB, IER2, JUNB, LITAF +5 more	View in SCUBA
Fibroblasts	Actin Cytoskeletal Organization Cytoskeletal	ACP1, AKR7A2, ARL3, CAPZB, DERL1, GDE1, LIMS1, NPTN +8 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more
Innate lymphoid cells	Lymphocyte Apoptosis Regulation Immune regulation	ANP32B, ARMCX3, CCDC69, CHD2, DHRS7, ELF1, FXYD5, GLIPR1 +14 more	View in SCUBA
Macrophages	Glycogen Metabolism Housekeeping	ARL2BP, BTF3L4, CAPN1, CD47, CRLS1, DCTD, DSTN, GLOD4 +24 more	View in SCUBA
Monocytes	Inflammatory Monocyte Activation Inflammatory	ALDOA, C11orf98, CLEC2B, CNIH4, CRIP1, GRINA, IFITM2, NBPF26 +5 more	View in SCUBA
Mucosal-associated invariant T cell	mRNA Decay Program RNA processing & translation	ATP6V0C, BCL7B, BTG1, BTG3, CCDC59, DDIT4, DUSP2, DYNLL2 +13 more
Natural Killer cells	Glucocorticoid Response Immune regulation	AREG, ARF6, BCLAF1, BEX2, BEX4, ELF1, ELL2, EPC1 +11 more	View in SCUBA

About the gene

Synonyms	my047, Vps55
Chromosome	8: 30095408-30177208
Predicted location	Membrane
Essential gene	No
Protein class	Predicted membrane proteins

Function

Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.