VCAM1 — Vascular cell adhesion molecule 1

VCAM1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

VCAM1's module in each cell type

Cell type	Module	Shares the module with
CD8⁺ T cells	Proliferating CD8 T cell Cell cycle	AHI1, ARL3, CDK6, GOLIM4, SLC7A5, SQLE, TNIP3, TNS3	View in SCUBA
Fibroblasts	Homeostatic Fibroblast Identity ECM production	ADGRL2, C1S, DCN, DKK3, DPYSL2, IL34, IL6ST, LUM +6 more	View in SCUBA
Gamma-delta T cells	Effector Cytokine Secretion Inflammation	APBA2, ASPH, CCL3, CCL4, CMC1, CYRIA, DTHD1, DTNBP1 +25 more
Pericytes	Inflammatory ECM Remodeling ECM remodeling	CCDC80, CD44, FHL2, FMO3, FN1, PDLIM3, RARRES2, TGFBI +1 more	View in SCUBA

About the gene

Synonyms	CD106
Chromosome	1: 100719742-100739045
Predicted location	Membrane, Secreted
Essential gene	No
Protein class	Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Biological process	Cell adhesion

Function

Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality- control checkpoint for entry into bone marrow by providing a 'don't- eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.