TNIP3 — TNFAIP3 interacting protein 3
TNIP3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TNIP3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1 +8 more | View in SCUBA |
| CD8⁺ T cells | Proliferating CD8 T cell Cell cycle | AHI1, ARL3, CDK6, GOLIM4, SLC7A5, SQLE, TNS3, VCAM1 | View in SCUBA |
| Gamma-delta T cells | Activation Stress Response Stress | ARHGAP9, ARHGEF12, ATF3, ATP6V0A2, GALNT6, GPR18, HIC1, HMCES +12 more | |
| Monocytes | NF-κB Counter-regulation Inflammatory | ABL2, C15orf48, CD274, GPR84, IL1RN, RHOH, TNFAIP8 | View in SCUBA |
About the gene
| Synonyms | ABIN-3, FLJ21162, LIND |
|---|---|
| Chromosome | 4: 121131408-121227466 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Inflammatory response |
Function
Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.