AHI1 — Abelson helper integration site 1
AHI1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AHI1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B, FKBP5 +13 more | View in SCUBA |
| CD8⁺ T cells | Proliferating CD8 T cell Cell cycle | ARL3, CDK6, GOLIM4, SLC7A5, SQLE, TNIP3, TNS3, VCAM1 | View in SCUBA |
| Innate lymphoid cells | NF-κB Inflammatory Activation Inflammation | CD83, FAM107B, FKBP2, GADD45A, HES4, KDM6B, MRPS36, PRPF4B +7 more | View in SCUBA |
| Smooth muscle cells | Notch-TGFbeta Signaling Development | CD81, CD9, CPED1, EDIL3, FHL1, GSN, JUND, MAF +3 more | View in SCUBA |
About the gene
| Synonyms | FLJ20069, JBTS3, ORF1 |
|---|---|
| Chromosome | 6: 135283407-135498434 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Developmental protein |
| Biological process | Cilium biogenesis/degradation, Differentiation |
Function
Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.