ILC Identity Program
Gene co-expression module in Innate lymphoid cells
| Category | Differentiation |
|---|---|
| Genes | 38 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include ZFP36L1 (RNA-binding protein, mRNA destabilization, regulates lymphocyte quiescence and ILC development), ARHGEF12 (Rho GEF, LARG), IL23R (IL-23 receptor, ILC3/ILC1 marker), LIF (leukemia inhibitory factor, cytokine), MGAT4A (N-acetylglucosaminyltransferase, glycosylation), AHR (aryl hydrocarbon receptor, ILC3 master regulator), KIT (CD117, stem cell factor receptor, ILC marker), RTKN2 (rhotekin-2, ILC3 marker), CD300LF (inhibitory receptor, ILC3/mast cell), DPP4 (CD26, ILC1 marker), PLXNC1 (plexin C1), F2R (PAR1, thrombin receptor), SPTLC2 (sphingolipid synthesis). The strong ILC1/ILC3 enrichment of multiple genes (IL23R, AHR, RTKN2, CD300LF, KIT, DPP4, LIF) and the presence of AHR (master ILC3 transcription factor) and ZFP36L1 (ILC development regulator) point to an ILC identity/differentiation program. This module likely reflects ILC1/ILC3 identity genes co-expressed in gut NK/ILC populations. ZFP36L1 as hub with strong membership is consistent with post-transcriptional regulation of ILC quiescence/differentiation.
Genes
AHR, APOL4, ARHGEF12, BLVRA, CD300LF, CDK2AP2, CEP83, COL4A4, DERL1, DPP4, EWSR1, F2R, GOLGA8B, HDAC9, ICOS, IFT57, IL23R, KIT, LIF, LNPEP, LYSMD2, MGAT4A, NARF, ORAI2, PDE4DIP, PHTF2, PLXNC1, RICTOR, RTKN2, SERINC3, SKAP1, SLC4A10, SPTLC2, STX17, TNFSF14, YPEL2, YWHAH, ZFP36L1
Most correlated modules
- NK JAK3 Signaling · correlation 0.89
- IFN-gamma Response · correlation 0.86
- NK Receptor Signaling · correlation 0.77
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.