MXD1 — MAX dimerization protein 1

MXD1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MXD1's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Heat-shock response Stress	AHSA1, BAG3, CACYBP, CCDC117, DNAJB6, DYNLL1, FKBP4, GADD45G +5 more	View in SCUBA
Enterocytes	Inflammatory hypoxic response Stress	CAPN2, ISG20, LRP10, MUC13, TM4SF20, TMBIM1, VEGFA	View in SCUBA
Gamma-delta T cells	Stress Epigenetic Silencing DNA/chromatin regulation	ALKBH5, ANKHD1, EPC2, FAM53C, NEU1, OTUD4, PHF1, PNO1 +8 more
Goblet cells	Inflammatory goblet response Immune function	ANXA1, B4GALT1, CAPN8, CEACAM6, DST, KRT20, LYPD8, MUC13 +8 more	View in SCUBA
Macrophages	Hypoxia-driven Activation Inflammatory	ACVR1B, ADAM10, ADAM9, ALCAM, ANO6, B3GNT2, BTG1, C5AR1 +33 more	View in SCUBA
Natural Killer cells	IFN-stimulated NK Inflammation	AKNA, APOL6, ATM, CTSC, ITGAL, MBP, PILRB, PTPRC +4 more	View in SCUBA
Neutrophils	Myeloid Inflammatory Activation Inflammatory	AQP9, CPD, FPR1, ITGAX, LITAF, NABP1, NAMPT, SDCBP +5 more

About the gene

Synonyms	bHLHc58, MAD, MAD1
Chromosome	2: 69897688-69942945
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins, Transcription factors
Molecular function	DNA-binding, Repressor
Biological process	Transcription, Transcription regulation

Function

Component of a transcriptional repressor complex together with MAX. In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing with MYC for MAX binding. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.