NCF1 — Neutrophil cytosolic factor 1
NCF1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NCF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B-cell identity B cell maturation | ALOX5AP, CD79B, HLA-DOB, IRF8, P2RX5, PLEKHF2, SEC62, SIAH2 +7 more | View in SCUBA |
| CD8⁺ T cells | Naive/Memory CD8 T cell maturation | C1orf162, CD48, CD55, EEF1B2, GPR155, IL7R, MATK, MYBL1 +3 more | View in SCUBA |
| Gamma-delta T cells | Immature T Cell T cell maturation | A1BG, ACP5, CD38, CD7, ID3, ITM2C, MZB1, NUDT14 +7 more | |
| Hematopoietic progenitor cells | Dendritic Cell Progenitor Myeloid development | BLNK, CCDC50, CD180, CLEC4A, HDAC9, HERPUD1, IRF8, LY86 +1 more | |
| Innate lymphoid cells | NK Receptor Signaling Cytotoxicity | B2M, CD48, CLEC2B, DCK, FCER1G, FKBP11, GPR108, HLA-A +12 more | View in SCUBA |
| Natural Killer cells | ILC1/NK Cytotoxic Cytotoxicity | A1BG, CASK, CLDND1, EIF3G, GZMK, ITM2C, KLRB1, PDCD4 +4 more | View in SCUBA |
About the gene
| Synonyms | NCF1A, NOXO2, p47phox, SH3PXD1A |
|---|---|
| Chromosome | 7: 74774011-74789315 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.