Dendritic Cell Progenitor
Gene co-expression module in Hematopoietic progenitor cells
| Category | Myeloid development |
|---|---|
| Genes | 10 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 10 genes have a known function matching the annotation |
Why this annotation
IRF8 is the master transcription factor for dendritic cell and monocyte development; CLEC4A (DCIR) marks plasmacytoid and myeloid DCs; NCF1 (p47-phox) is a myeloid NADPH oxidase component; LY86/MD-1 is expressed on B-cells and macrophages; CD180/RP105 is a TLR4 homolog on B-cells and myeloid cells; BLNK is classically a B-cell linker but is also expressed in pDC precursors; HDAC9 regulates myeloid/DC differentiation. Together these point strongly to a dendritic cell progenitor / plasmacytoid DC program driven by IRF8. The BLNK/CD180 signal may reflect the shared lymphoid-myeloid origin of pDCs.
Genes
BLNK, CCDC50, CD180, CLEC4A, HDAC9, HERPUD1, IRF8, LY86, NCF1, NIBAN3
Most correlated modules
- Myeloid Innate Immune · correlation 0.89
- ILC/NK Development · correlation 0.86
- Lymphocyte Signaling · correlation 0.85
- Regulatory T-cell State · correlation 0.76
- T/NK Cell Identity · correlation 0.72
- MHC-I Antigen Presentation · correlation 0.70
- Lymphoid Progenitor TFs · correlation 0.63
- ILC3/γδT Priming · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.