CDCA2 — Cell division cycle associated 2
CDCA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CDCA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitosis & Cytokinesis Cell cycle | CEP55, CKAP2L, NUSAP1, RACGAP1, SGO1, TACC3, TOP2A | View in SCUBA |
| Goblet cells | Chromosome Segregation Cell cycle | ANLN, CDCA8, CKAP2L, HJURP, KIF11, KIFC1, NCAPG, NDC80 +3 more | View in SCUBA |
About the gene
| Synonyms | PPP1R81, Repo-Man |
|---|---|
| Chromosome | 8: 25459199-25507911 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.