Chromosome Segregation
Gene co-expression module in Goblet cells
| Category | Cell cycle |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes: ANLN (anillin, cytokinesis contractile ring), SKA1 (spindle and kinetochore-associated), NDC80 (kinetochore complex), KIF11 (Eg5 kinesin, bipolar spindle), CDCA8 (chromosomal passenger complex), NCAPG (condensin complex), TACC3 (centrosome/spindle), PRC1 (microtubule bundling at spindle midzone), CKAP2L (spindle), CDCA2 (Repo-Man, chromosome decondensation), HJURP (CENPA chaperone), KIFC1 (minus-end kinesin, spindle organization). All core membership. This module is tightly focused on chromosome segregation mechanics: kinetochore–microtubule attachment (NDC80, SKA1), bipolar spindle formation (KIF11, TACC3), and cytokinesis initiation (ANLN, PRC1). Distinguished from M42 by emphasis on chromosome-spindle interface rather than checkpoint kinases.
Genes
ANLN, CDCA2, CDCA8, CKAP2L, HJURP, KIF11, KIFC1, NCAPG, NDC80, PRC1, SKA1, TACC3
Most correlated modules
- Mitotic Proliferation · correlation 0.96
- Mitotic Spindle Assembly · correlation 0.96
- S/G2 Preparation · correlation 0.89
- FOXM1-driven G2/M · correlation 0.88
- G2/M Cyclin Program · correlation 0.88
- Basal Transcription · correlation 0.61
- S-phase DNA Replication · correlation 0.57
- Replication Fork Checkpoint · correlation 0.57
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.