HJURP — Holliday junction recognition protein
HJURP belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HJURP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | G2/M Cell Cycle Cell cycle | CCNF, CDC25C, CDCA3, CDCA8, DEPDC1B, FAM83D, FBXO43, PRC1 +1 more | View in SCUBA |
| Goblet cells | Chromosome Segregation Cell cycle | ANLN, CDCA2, CDCA8, CKAP2L, KIF11, KIFC1, NCAPG, NDC80 +3 more | View in SCUBA |
About the gene
| Synonyms | DKFZp762E1312, FAKTS, hFLEG1, URLC9 |
|---|---|
| Chromosome | 2: 233833416-233854566 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Chaperone, DNA-binding |
| Biological process | Cell cycle |
Function
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.