Pre-mRNA Splicing
Gene co-expression module in Gamma-delta T cells
| Category | RNA processing & translation |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 12 of 20 genes have a known function matching the annotation |
Why this annotation
Top hub BCLAF1 is a dual-function apoptosis/splicing regulator. RBM39 is a splicing factor targeted by indisulam. CLK1 phosphorylates SR proteins to regulate splice-site selection. WBP11 (splicing), RSRC2 (splicing coactivator), DDX24 and DDX3X (RNA helicases involved in pre-mRNA processing), NUP58 (nuclear pore, mRNA export), CNOT1 (CCR4-NOT deadenylase complex), MAPK1IP1L (MAPK pathway/splicing), COPS2 (COP9 signalosome, ubiquitin-regulated transcription). The module is core-coherent and dominated by splicing regulation and mRNA processing factors. Neighbor M80 also features hnRNPs and splicing factors, reinforcing this RNA-processing neighborhood.
Genes
BCLAF1, CENPC, CLK1, CNOT1, COG3, COPS2, DDX24, DDX3X, EPC1, KPNA4, MAPK1IP1L, NUP58, RAB5A, RBM39, RLF, RSRC2, STK17B, TSPYL1, WBP11, ZNF394
Most correlated modules
- Ubiquitin-p53 Regulation · correlation 0.94
- hnRNP Splicing Complex · correlation 0.92
- Chromatin Epigenetic Regulation · correlation 0.90
- ER Proteotoxic Stress · correlation 0.89
- MAPK Kinase Signaling · correlation 0.89
- DNA Damage Ubiquitin · correlation 0.86
- Hypoxia Stress Response · correlation 0.86
- Wnt-STAT3 Signaling · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.