FEN1 — Flap structure-specific endonuclease 1
FEN1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
FEN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | DNA Replication Cell cycle | CDC45, CENPH, DHFR, GINS2, MCM3, MCM5, MCM7, PCNA +3 more | View in SCUBA |
| CD8⁺ T cells | DNA Replication Fork Cell cycle | CDC6, CDT1, CHAF1A, CTNNAL1, DHFR, DUT, LIG1, PCNA +5 more | View in SCUBA |
| Endothelial | S-phase Proliferation Cell cycle | ATAD2, ATAD5, BRCA1, BRCA2, CENPH, CENPK, CENPU, DHFR +11 more | View in SCUBA |
| Gamma-delta T cells | S-phase Replication Cell cycle | ATAD2, ATAD5, BRCA2, CDT1, CENPH, CENPM, CENPU, CLSPN +13 more | |
| Goblet cells | S-phase DNA Replication Cell cycle | ASF1B, BRCA1, CDC6, CENPU, DHFR, MYBL2, PCLAF, TK1 +1 more | View in SCUBA |
| Hematopoietic progenitor cells | DNA Replication S-phase Cell cycle | CDT1, CENPH, CENPK, CHEK1, E2F1, GINS2, GMNN, PCLAF +4 more | |
| Macrophages | S-phase DNA Replication Cell cycle | ATAD2, ATAD5, BARD1, BRCA1, CENPK, CENPM, CENPU, CLSPN +31 more | View in SCUBA |
| Natural Killer cells | DNA Replication Cell cycle | ATAD2, DHFR, LIG1, MCM7, PCNA, TK1, TMEM106C, UHRF1 | View in SCUBA |
About the gene
| Synonyms | FEN-1, MF1, RAD2 |
|---|---|
| Chromosome | 11: 61792911-61797238 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Endonuclease, Exonuclease, Hydrolase, Nuclease |
| Biological process | DNA damage, DNA repair, DNA replication |
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.