CHD8 — Chromodomain helicase DNA binding protein 8
CHD8 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CHD8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | AKT survival signaling TCR/AP1/NFKb pathway | ABHD2, AKT1, ARL14EP, ATF7, ATP6AP1, GNGT2, IP6K2, ITSN2 +10 more | View in SCUBA |
| Gamma-delta T cells | DNA Damage Response DNA/chromatin regulation | AP1B1, CCAR1, DOCK2, EP400, ERBIN, GOLM2, IPO8, LRBA +17 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Organization Cytoskeletal | ARAP2, CTNNB1, DYNC1H1, EP400, NFATC2, RASSF2, RNF4, SRPRA +4 more |
About the gene
| Synonyms | DUPLIN, HELSNF1, KIAA1564 |
|---|---|
| Chromosome | 14: 21385194-21456126 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Activator, Chromatin regulator, DNA-binding, Hydrolase, Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
ATP-dependent chromatin-remodeling factor, it slides nucleosomes along DNA; nucleosome sliding requires ATP. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. Regulates alternative splicing of a core group of genes involved in neuronal differentiation, cell cycle and DNA repair. Enables H3K36me3-coupled transcription elongation and co- transcriptional RNA processing likely via interaction with HNRNPL.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.