RNF4 — Ring finger protein 4
RNF4 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RNF4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Chromatin Remodeling DNA/chromatin regulation | ACTN4, ANP32E, AP2B1, CCDC82, EIF2B1, EXOSC10, FAR1, FLII +17 more | |
| Macrophages | RNA Processing Transport Housekeeping | BCL2, CDYL, CPSF6, DHX15, DHX9, EFR3A, EXOC1, FBXO38 +18 more | View in SCUBA |
| Mucosal-associated invariant T cell | Cytoskeletal Organization Cytoskeletal | ARAP2, CHD8, CTNNB1, DYNC1H1, EP400, NFATC2, RASSF2, SRPRA +4 more |
About the gene
| Synonyms | RES4-26, SLX5, SNURF |
|---|---|
| Chromosome | 4: 2462220-2515857 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding, Transferase |
| Biological process | Transcription, Transcription regulation, Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys- 48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Catalyzes ubiquitination of sumoylated PARP1 in response to PARP1 trapping to chromatin, leading to PARP1 removal from chromatin by VCP/p97.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.