Cytoskeletal Organization
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Cytoskeletal |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
Top hub DYNC1H1 (cytoplasmic dynein heavy chain, microtubule motor), TACC1 (microtubule/centrosome-associated), and TPM4 (tropomyosin, actin cytoskeleton) anchor a cytoskeletal program. CTNNB1 (beta-catenin, Wnt/cytoskeletal), NFATC2 (NFAT TF, T cell activation), CHD8 and EP400 (chromatin remodelers), YTHDF2 (m6A RNA modification), RNF4 (ubiquitin E3 ligase), and RASSF2 (Ras-association, apoptosis/cytoskeletal) add chromatin and signaling dimensions. The dominant cytoskeletal/motor theme (dynein, TACC1, TPM4) distinguishes this module. The co-expression with chromatin remodelers may reflect coupled cytoskeletal-nuclear reorganization in T cell activation.
Genes
ARAP2, CHD8, CTNNB1, DYNC1H1, EP400, NFATC2, RASSF2, RNF4, SRPRA, TACC1, TPM4, YLPM1, YTHDF2
Most correlated modules
- Co-transcriptional Splicing · correlation 0.85
- Transcription Factor Activity · correlation 0.84
- Nuclear-Cytoskeletal Organization · correlation 0.81
- Cellular Maintenance · correlation 0.81
- Nuclear-Cytoplasmic Transport · correlation 0.81
- T cell Activation Signaling · correlation 0.80
- Circadian Transcriptional Regulation · correlation 0.80
- PI3K-Calcineurin Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.