EP400 — E1A binding protein p400

EP400 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

EP400's module in each cell type

Cell type	Module	Shares the module with
Gamma-delta T cells	DNA Damage Response DNA/chromatin regulation	AP1B1, CCAR1, CHD8, DOCK2, ERBIN, GOLM2, IPO8, LRBA +17 more
Macrophages	RNA Processing Housekeeping Housekeeping	BAZ1A, BDP1, CCAR1, CCDC88A, CLIP1, CUL5, DHX36, DNM1L +32 more	View in SCUBA
Mucosal-associated invariant T cell	Cytoskeletal Organization Cytoskeletal	ARAP2, CHD8, CTNNB1, DYNC1H1, NFATC2, RASSF2, RNF4, SRPRA +4 more

About the gene

Synonyms	CAGH32, DKFZP434I225, KIAA1498, KIAA1818, P400, TNRC12
Chromosome	12: 131949942-132080460
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Plasma proteins, Predicted intracellular proteins
Molecular function	Chromatin regulator, DNA-binding, Helicase, Hydrolase

Function

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.