MFGE8 — Milk fat globule EGF and factor V/VIII domain containing
MFGE8 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MFGE8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Complement Innate Immune Inflammation | C1R, C1S, CD47, CNDP2, COL5A2, CTSS, GRINA, GSDMD +9 more | View in SCUBA |
| Fibroblasts | Wnt-BMP Fibroblast Developmental | ABCC4, BMP7, EMID1, ETS1, GJA1, GNG2, LEF1, PAPLN +5 more | View in SCUBA |
| Innate lymphoid cells | ILC1 Actin Motility Cytoskeleton & motility | ACAP1, ARHGDIB, CORO1A, DGCR6L, EVL, GPSM3, HEXA, LCK +14 more | View in SCUBA |
| Pericytes | Pericyte Vascular Tone Developmental | ADAP2, CHCHD10, CSPG4, FOXS1, LINGO1, MCAM, PGF, PTGIR +3 more | View in SCUBA |
| Smooth muscle cells | Oxidative Muscle Metabolism Mitochondrial & OxPhos | CAV2, COX7A1, CRIP2, FXYD1, HCFC1R1, LGR6, MGST3, NDUFB7 +2 more | View in SCUBA |
About the gene
| Synonyms | BA46, EDIL1, hP47, HsT19888, MFG-E8, OAcGD3S, SED1, SPAG10 |
|---|---|
| Chromosome | 15: 88898683-88913468 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Angiogenesis, Cell adhesion, Fertilization |
Function
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Main constituent of aortic medial amyloid
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.