PGF — Placental growth factor
PGF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PGF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | CXCL12 Angiogenic Chemotaxis Chemotaxis | ACKR3, AFAP1L1, ARHGAP18, ARHGEF7, CHST1, CXCR4, FHL3, FSCN1 +15 more | View in SCUBA |
| Pericytes | Pericyte Vascular Tone Developmental | ADAP2, CHCHD10, CSPG4, FOXS1, LINGO1, MCAM, MFGE8, PTGIR +3 more | View in SCUBA |
| Smooth muscle cells | Arteriolar Mural Cells Development | ESAM, FOXS1, GJA4, LINGO1, NDUFA4L2, NGF, OR51E1, OR51E2 +3 more | View in SCUBA |
About the gene
| Synonyms | D12S1900, PGFL, PIGF, PLGF, PlGF-2, SHGC-10760 |
|---|---|
| Chromosome | 14: 74941834-74955626 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, FDA approved drug targets, Plasma proteins, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Developmental protein, Growth factor, Heparin-binding, Mitogen |
| Biological process | Angiogenesis, Differentiation |
Function
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.