CREBZF — CREB/ATF bZIP transcription factor
CREBZF belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CREBZF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Post-transcriptional regulation RNA processing | BCL11B, CCDC14, CHD2, CHD6, DDX39B, DNASE1, EVI2B, FAM78A +21 more | View in SCUBA |
| Macrophages | Pre-mRNA Splicing Housekeeping | AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, DMTF1, FAM133B +20 more | View in SCUBA |
| Mucosal-associated invariant T cell | Apoptosis Regulation Immune regulation | ARF4, ARRDC3, CARD8, CFLAR, MAPRE2, NABP1, PCF11, PPP1R10 +1 more |
About the gene
| Synonyms | ZF |
|---|---|
| Chromosome | 11: 85657742-85682908 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Transcription factors |
| Biological process | Transcription, Transcription regulation |
Function
Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.