Pre-mRNA Splicing
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 29 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include PNISR (PNN-interacting serine/arginine-rich protein, splicing), N4BP2L2 (NKAP, splicing/transcriptional repressor), ANKRD12 (ankyrin repeat domain, transcriptional corepressor), PRPF38B (pre-mRNA processing factor 38B, splicing), RBM5 (RNA-binding motif protein 5, splicing/apoptosis), LUC7L3 (splicing factor), ARGLU1 (arginine and glutamate rich, splicing coactivator), RSRP1 (arginine/serine-rich protein, splicing), SREK1 (splicing regulatory glutamine/lysine-rich protein), RBM12B (RNA-binding), DMTF1 (transcription factor), TRIM38 (E3 ubiquitin ligase, innate immune), BRD2 (bromodomain, chromatin/transcription), ZKSCAN1 (zinc finger transcription factor), MYO1F (myosin IF, actin-based motor, macrophage function). The dominant theme is pre-mRNA splicing regulation, consistent with neighbors M88, M56, M122. PNISR, N4BP2L2, PRPF38B, LUC7L3, ARGLU1, RSRP1, SREK1, RBM5 are all splicing-associated. The mono_mac enrichment for many genes is consistent with active transcriptional/splicing programs in monocyte-derived macrophages.
Genes
AAK1, ANKRD12, ANKRD13D, ARGLU1, BRD2, C3orf62, CREBZF, DMTF1, FAM133B, LUC7L3, MDM4, MYO1F, N4BP2L2, NKTR, NSD1, PNISR, PRPF38B, PTAR1, RBBP6, RBM12B, RBM5, RSRP1, SH3BP2, SREK1, TRIM38, TTC14, UBXN7, ZKSCAN1, ZNF791
Most correlated modules
- Pre-mRNA Splicing · correlation 0.96
- mRNA Splicing Processing · correlation 0.95
- Splicing Factor Regulation · correlation 0.94
- Chromatin Regulatory Genes · correlation 0.94
- RNA Splicing Processing · correlation 0.93
- Mixed Regulatory Signaling · correlation 0.91
- Transcriptional Elongation · correlation 0.90
- Transcriptional Repression · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.