Effector Cell Migration
Gene co-expression module in Gamma-delta T cells
| Category | migration & adhesion |
|---|---|
| Genes | 26 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 26 genes have a known function matching the annotation |
Why this annotation
This module has a mixed but interpretable profile. APOBEC3G (antiviral deaminase, expressed in activated T cells), CD52 (highly expressed on lymphocytes, shed during activation), CTSC (cathepsin C, required for granzyme activation), TRPV2 (expressed on NK/T cells, regulates cytotoxic function), ITGB7 (gut-homing integrin), SELPLG (PSGL-1, selectin ligand for migration), ZAP70 (TCR-proximal kinase), ADAM8/ADAM15 (metalloproteinases mediating shedding and migration), and GLRX (glutaredoxin, redox) collectively point to an effector T cell migration and adhesion program with cytotoxic potential. ITGB7 and SELPLG are prominent migration/adhesion molecules, while CTSC and APOBEC3G mark effector cytotoxic function.
Genes
ADAM15, ADAM8, ANXA2, APOBEC3G, CD52, CTSC, DSTN, FUT11, GLIPR2, GLRX, ITGB7, MVP, NHERF1, NPRL2, PPM1M, PTRH1, RAB37, RNF167, SELPLG, STING1, TIMP1, TMBIM1, TMEM109, TRPV2, YWHAB, ZAP70
Most correlated modules
- TCR Proximal Signaling · correlation 0.95
- Lymphocyte Homeostatic Regulation · correlation 0.93
- Coinhibitory Checkpoint · correlation 0.92
- γδ T Cell Identity · correlation 0.87
- Effector IFN Response · correlation 0.84
- T Cell Survival · correlation 0.84
- T-bet Effector Differentiation · correlation 0.83
- NKG2D Cytotoxic Activation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.