APOBEC3G — Apolipoprotein B mRNA editing enzyme catalytic subunit 3G
APOBEC3G belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
APOBEC3G's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon-stimulated genes Anti-viral | ARPC4, ARPC5L, BAK1, BST2, DCTN3, ECH1, ETFB, FAM104A +14 more | View in SCUBA |
| Gamma-delta T cells | Effector Cell Migration migration & adhesion | ADAM15, ADAM8, ANXA2, CD52, CTSC, DSTN, FUT11, GLIPR2 +17 more | |
| Innate lymphoid cells | NK Homing Circulating Homing & TEM | ADD3, ANXA1, C16orf54, C1orf162, CAPG, CASP4, CAST, CDKN2D +37 more | View in SCUBA |
| Monocytes | Inflammasome Activation Innate immunity | AIM2, ARID5B, BATF3, BST2, CASP5, CD47, CNDP2, CYSTM1 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mature Effector MAIT T cell maturation | ADD3, ANTKMT, CCL5, CXXC5, FHL3, GZMK, ITGA6, ITGB2 +7 more | |
| Natural Killer cells | NK Cytotoxic Signaling Cytotoxicity | B2M, CALM1, CD48, GLIPR2, HCST, MYL12A, TMSB10, TRGC1 +1 more | View in SCUBA |
About the gene
| Synonyms | bK150C2.7, CEM15, dJ494G10.1, FLJ12740, MDS019 |
|---|---|
| Chromosome | 22: 39077067-39087743 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase |
| Biological process | Antiviral defense, Host-virus interaction, Immunity, Innate immunity |
Function
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase- dependent and -independent mechanisms. Exhibits potent antiviral activity against Vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against simian immunodeficiency viruses (SIVs), hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV). May inhibit the mobility of LTR and non-LTR retrotransposons.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.