MTCH2 — Mitochondrial carrier 2
MTCH2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MTCH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Interferon-stimulated genes Anti-viral | APOBEC3G, ARPC4, ARPC5L, BAK1, BST2, DCTN3, ECH1, ETFB +14 more | View in SCUBA |
| Endothelial | Respiratory Chain Complex Mitochondrial & OxPhos | ATP5MG, CHCHD2, HSBP1, NDUFB11, NDUFS8, NDUFV2, SNRPD2, UQCR10 | View in SCUBA |
| Enterocytes | Mitochondrial Energy Metabolism Mitochondrial & OxPhos | ALDH1A1, ALDH3A2, CPS1, GALM, GCNT1, GPI, GSTM4, NDUFV1 +2 more | View in SCUBA |
| Goblet cells | Mitochondrial OxPhos Mitochondrial & OxPhos | ATP5MC1, ATP5MC3, ATP5PF, DBI, NDUFA12, NDUFB2, TPI1 | View in SCUBA |
| Innate lymphoid cells | ILC1 Cytoskeletal Metabolic Cytoskeleton & motility | ATP5F1B, ATXN10, CCT7, CD82, DNPH1, GADD45GIP1, HMGA1, MEA1 +14 more | View in SCUBA |
| Macrophages | Mitochondrial Housekeeping Mitochondrial & OxPhos | BLOC1S2, BUD31, C14orf119, CCT5, CDC26, DGUOK, EIF2S1, GADD45GIP1 +11 more | View in SCUBA |
About the gene
| Synonyms | SLC25A50 |
|---|---|
| Chromosome | 11: 47617315-47642607 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins, Transporters |
| Biological process | Transport |
Function
Protein insertase that mediates insertion of transmembrane proteins into the mitochondrial outer membrane. Catalyzes insertion of proteins with alpha-helical transmembrane regions, such as signal-anchored, tail-anchored and multi-pass membrane proteins. Does not mediate insertion of beta-barrel transmembrane proteins. Also acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis (By similarity). Regulates the quiescence/cycling of hematopoietic stem cells (HSCs) (By similarity). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs) (By similarity). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.