HPS5 — HPS5 biogenesis of lysosomal organelles complex 2 subunit 2
HPS5 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HPS5's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | NF-kB epithelial activation Inflammation | BNIP5, CCL20, EHD4, IL6ST, NFKBIA, RAB8B, RAP1B, TMPRSS2 +1 more | View in SCUBA |
| Macrophages | Myeloid Innate Signaling Innate immunity | ADCY7, ARHGAP18, BMP2K, C3AR1, C6orf62, CD46, CD84, CLTC +34 more | View in SCUBA |
About the gene
| Synonyms | AIBP63, BLOC2S2, RU2 |
|---|---|
| Chromosome | 11: 18278668-18322198 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
Function
May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Regulates intracellular vesicular trafficking in fibroblasts. May be involved in the regulation of general functions of integrins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.