NFKBIA — NFKB inhibitor alpha

NFKBIA belongs to a gene co-expression module in 16 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

NFKBIA's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate Early NFkB BCR/AP1/NFKb pathway	ARL5B, CDKN1A, CSRNP1, DUSP2, EGR1, EGR3, IER2, PPP1R15B +3 more	View in SCUBA
CD4⁺ T cells	Immediate Early AP-1 TCR/AP1/NFKb pathway	BTG2, CD69, CDKN1A, DUSP1, EGR1, FOS, FOSB, IER2 +6 more	View in SCUBA
CD8⁺ T cells	Tc17 program Tc17 program	ABI3, ABRACL, CAPG, CCDC85B, FKBP11, GPR34, IL17A, KLRB1 +4 more	View in SCUBA
Endothelial	NF-κB Activation Inflammation	C2CD4B, HSPA6, ICAM5, IER3, MAP3K8, NFKBID, PMAIP1, PTGS2 +5 more	View in SCUBA
Enterocytes	NF-kB epithelial activation Inflammation	BNIP5, CCL20, EHD4, HPS5, IL6ST, RAB8B, RAP1B, TMPRSS2 +1 more	View in SCUBA
Fibroblasts	NF-κB Immediate Early Inflammatory	ATF3, DNAJA1, DUSP1, HLA-E, HSPA8, IRF1, MAFF, NFKBIZ +4 more	View in SCUBA
Gamma-delta T cells	TCR Early Activation TCR Signaling	BTG1, BTG2, CD69, CIRBP, CXCR4, DUSP1, EIF1, ETV3 +15 more
Goblet cells	NF-κB Stress Response Stress	ATF3, CCNL1, EGR3, IER3, MAFF, MYADM, NR4A1, RHOB +1 more	View in SCUBA
Innate lymphoid cells	NF-κB Inflammatory Activation Inflammation	CDKN1A, CSRNP1, DUSP1, DUSP2, DUSP6, ELL2, EZR, FOS +26 more	View in SCUBA
Lymphatic endothelial	NF-κB Negative Feedback Inflammation	BMP2, C2CD4B, ICAM1, IRF8, KLF6, MAFF, NFIL3, PRNP +4 more	View in SCUBA
Macrophages	Early response genes Inflammatory	ATF3, BAG3, BTG2, CGAS, DNAJA1, DNAJA4, DNAJB1, DNAJB4 +39 more	View in SCUBA
Monocytes	Immediate-Early Inflammatory Inflammatory	CXCL2, CXCL3, CXCL8, DUSP2, EGR1, EGR2, NFKBIZ, OTUD1 +3 more	View in SCUBA
Mucosal-associated invariant T cell	NF-κB Negative Feedback Immune regulation	ARL4A, BCAS2, CSRNP1, CXCR4, ENSG00000285976, IDS, ITPRIP, NFKBIB +7 more
Natural Killer cells	Integrated Stress Response Stress	FAM43A, IER2, IER5, MARCKSL1, NFKBIZ, PMAIP1, PPP1R15A, PPP1R15B +1 more	View in SCUBA
Neutrophils	NF-κB Activation Inflammatory	EHD1, GRAMD1A, NBN, NFKB2, NFKBIZ, PLAUR, PLEK, PLK3 +6 more
Smooth muscle cells	XBP1 UPR Response Protein processing & ER	ADAMTS10, AKAP13, ATP1A1, BATF3, BNIP3L, CHRD, DLC1, HERPUD1 +5 more	View in SCUBA

About the gene

Synonyms	IkappaBalpha, IKBA, MAD-3, NFKBI
Chromosome	14: 35401079-35404749
Predicted location	Intracellular
Essential gene	No
Protein class	Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Biological process	Host-virus interaction

Function

Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals. On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.