RAP1B — RAP1B, member of RAS oncogene family
RAP1B belongs to a gene co-expression module in 9 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RAP1B's module in each cell type
About the gene
| Synonyms | DKFZp586H0723, K-REV, RAL1B |
|---|---|
| Chromosome | 12: 68610855-68671901 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Enzymes, Essential proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Hydrolase |
Function
GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.