IL15RA — Interleukin 15 receptor subunit alpha
IL15RA belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IL15RA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine receptor signaling Immune regulation | C21orf91, C6orf62, DDX3X, HNRNPH1, ID2, IL18RAP, MMD, PERP +1 more | View in SCUBA |
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL10, CXCL11 +18 more | View in SCUBA |
| Fibroblasts | NF-κB Inflammatory Activation Inflammatory | BIRC3, CD40, CTSS, DRAM1, HAPLN3, IL32, LAP3, STAT1 +5 more | View in SCUBA |
About the gene
| Synonyms | CD215, IL-15RA |
|---|---|
| Chromosome | 10: 5943639-5978187 |
| Predicted location | Intracellular, Membrane, Secreted |
| Essential gene | No |
| Protein class | CD markers, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins |
| Molecular function | Receptor |
Function
High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells (By similarity). In neutrophils, binds and activates kinase SYK in response to IL15 stimulation. In neutrophils, required for IL15- induced phagocytosis in a SYK-dependent manner. Expression of different isoforms may alter or interfere with signal transduction. Does not bind IL15. Does not bind IL15. Does not bind IL15. Does not bind IL15
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.