CXCL10 — C-X-C motif chemokine ligand 10
CXCL10 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCL10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | IFN-gamma Response Inflammation | APOL2, APOL6, BATF2, CARD16, CASP1, CD40, CXCL11, CXCL9 +18 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | APOL6, BATF2, GBP1, IFI44L, IFIT2, IFIT3, ISG15, MX1 +6 more | View in SCUBA |
| Glial cells | NF-κB/IFN Inflammatory Inflammation | BIRC3, CTSS, CXCL2, CXCL9, FDCSP, HAPLN3, ICAM1, PTX3 +4 more | View in SCUBA |
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Monocytes | IFN-gamma Response Antiviral | APOL2, APOL6, ETV7, GBP1, GBP4, GBP5, IFIH1, ISG15 +6 more | View in SCUBA |
About the gene
| Synonyms | C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10 |
|---|---|
| Chromosome | 4: 76021118-76023497 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.