DRAM1 — DNA damage regulated autophagy modulator 1
DRAM1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DRAM1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | NF-κB Inflammatory Activation Inflammatory | BIRC3, CD40, CTSS, HAPLN3, IL15RA, IL32, LAP3, STAT1 +5 more | View in SCUBA |
| Lymphatic endothelial | NRF2 Oxidative Stress Stress | B4GALT1, CTTNBP2NL, DDX21, GCH1, HNRNPF, MSN, NFE2L2, PDXDC1 +11 more | View in SCUBA |
| Macrophages | Inflammatory Monocyte Activation Inflammatory | ACTN1, ADAM8, AGTRAP, ANXA2, ANXA4, C15orf48, CD44, CD9 +21 more | View in SCUBA |
About the gene
| Synonyms | DRAM, FLJ11259 |
|---|---|
| Chromosome | 12: 101877580-102012130 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Biological process | Apoptosis, Autophagy |
Function
Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.