RANBP2 — RAN binding protein 2
RANBP2 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RANBP2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Oxidative/ER stress Stress | ASAH1, ATP6V0D1, B4GALT1, FAM210A, FOSL2, GEM, GZF1, HIC1 +6 more | View in SCUBA |
| CD4⁺ T cells | TCR early activation TCR/AP1/NFKb pathway | ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2 +11 more | View in SCUBA |
| Gamma-delta T cells | Chromatin Remodeling Signaling DNA/chromatin regulation | AKAP13, BPTF, CARNMT1, CCDC6, CFLAR, CLASP1, CLASP2, DOCK10 +23 more | |
| Innate lymphoid cells | Prostaglandin-AP1 Response Inflammation | ARIH1, ARL5B, CCNT1, CHD1, CXCL2, ETV3, FOSL2, IRF2BP2 +12 more | View in SCUBA |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear-Cytoplasmic Transport Housekeeping | AP1G1, CNOT1, INO80D, JARID2, NAA50, NUP98, PLEKHA2, PLEKHM1 +3 more | |
| Natural Killer cells | NK Immune Checkpoint Immune regulation | AKAP13, CHD1, G3BP2, LIMS1, MORF4L2, P2RY10, PTPN22, SAMSN1 +1 more | View in SCUBA |
About the gene
| Synonyms | ADANE, ANE1, NUP358 |
|---|---|
| Chromosome | 2: 108719482-108785810 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Disease related genes, Essential proteins, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Molecular function | RNA-binding, Transferase |
| Biological process | mRNA transport, Protein transport, Translocation, Transport, Ubl conjugation pathway |
Function
E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E- dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl- prolyl cis-trans isomerase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.