Nuclear-Cytoplasmic Transport
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 9 of 12 genes have a known function matching the annotation |
Why this annotation
The top hub genes in this module are NUP98 (nuclear pore complex, nucleocytoplasmic transport) and RANBP2 (nuclear pore complex, RanGAP1 interaction), alongside AP1G1 (AP-1 adaptor complex, vesicular trafficking), PLEKHA2 (PH domain, membrane signaling), PLEKHM1 (Rab7 effector, endolysosomal trafficking), INO80D (chromatin remodeling), ZNF644 (transcription factor), JARID2 (PRC2 complex), SAR1A (COPII vesicle formation), SREBF2 (sterol regulatory transcription factor), CNOT1 (CCR4-NOT deadenylase complex), NAA50 (N-terminal acetyltransferase). Multiple genes point to nuclear pore/nucleocytoplasmic transport (NUP98, RANBP2) and vesicular/membrane trafficking (AP1G1, SAR1A, PLEKHM1). This is a housekeeping module combining nuclear transport and intracellular trafficking functions, consistent with the uniform low expression pattern.
Genes
AP1G1, CNOT1, INO80D, JARID2, NAA50, NUP98, PLEKHA2, PLEKHM1, RANBP2, SAR1A, SREBF2, ZNF644
Most correlated modules
- Hypoxia-ER Stress · correlation 0.87
- Post-translational Regulation · correlation 0.87
- Cellular Maintenance · correlation 0.86
- TCR Signal Attenuation · correlation 0.81
- Cytoskeletal Organization · correlation 0.81
- Transcription Factor Activity · correlation 0.80
- Epigenetic Chromatin Regulation · correlation 0.77
- T cell Quiescence · correlation 0.76
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.