MMP19 — Matrix metallopeptidase 19
MMP19 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MMP19's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Cytokine Inflammatory Response Inflammatory | CXCL2, DNAJB4, GFPT2, HES4, MAP3K8, RASL11A, RGCC, RND3 +4 more | View in SCUBA |
| Macrophages | Osmotic Stress Response Stress | ANKRD28, BZW1, CD109, CXCL8, CYB5R4, CYTIP, DUSP4, EMP3 +25 more | View in SCUBA |
| Monocytes | Tissue-destructive Macrophage Lysosomal & pahgocytosis | ACP5, ANKH, BCAT1, ENG, FABP5, ID3, IL10, KIFC3 +7 more | View in SCUBA |
About the gene
| Synonyms | MMP18, RASI-1 |
|---|---|
| Chromosome | 12: 55835433-55842966 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins |
| Molecular function | Developmental protein, Hydrolase, Metalloprotease, Protease |
| Biological process | Angiogenesis, Collagen degradation, Differentiation |
Function
Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.